Table 2. Results of subgroup analysis of HR ratio of OS of cancers with low PNI level.
| Subgroup analysis | No. of studies | No. of patients | Pooled HR [95%CI] | Meta-regression (P value) | Heterogeneity I2 (%) | Heterogeneity P value |
|---|---|---|---|---|---|---|
| Region | ||||||
| Japan | 14 | 3160 | 1.99 [1.68, 2.35] | 0.000 | 50.5 | 0.013 |
| China | 6 | 3161 | 1.65 [1.35, 2.03] | 0.000 | 61.3 | 0.024 |
| Korea | 1 | 314 | 3.45 [1.77, 6.72] | 0.000 | – | – |
| Scotland | 1 | 374 | 1.33 [0.99, 1.79] | 0.059 | – | – |
| Sample size | ||||||
| < 200 | 7 | 872 | 1.82 [1.62, 2.07] | 0.000 | 49.4 | 0.065 |
| ≧ 200 | 15 | 6137 | 1.85 [1.60, 2.15] | 0.000 | 50.5 | 0.013 |
| Cut-off value | ||||||
| < 45 | 4 | 498 | 2.62 [1.91, 3.60] | 0.000 | 0.0 | 0.782 |
| ≧ 45 | 18 | 6511 | 1.74 [1.54, 1.97] | 0.000 | 48.6 | 0.011 |
| Type of cancer | ||||||
| Gastric cancer | 7 | 2381 | 2.07 [1.72, 2.49] | 0.000 | 23.7 | 0.249 |
| Colorectal carcinoma | 7 | 2677 | 1.93 [1.39, 2.68] | 0.000 | 69.4 | 0.003 |
| Hepatocellular carcinoma | 4 | 927 | 1.75 [1.32, 2.32] | 0.000 | 54.4 | 0.087 |
| Pancreatic cancer | 3 | 766 | 1.58 [1.28, 1.94] | 0.000 | 0.0 | 0.712 |
| Esophageal carcinoma | 1 | 258 | 1.80 [1.16, 2.81] | 0.009 | ||
| Quality Score (NOS) | ||||||
| < 6 | 8 | 2074 | 1.85 [1.56, 2.19] | 0.000 | 14.2 | 0.319 |
| ≧ 6 | 14 | 4935 | 1.83 [1.62, 2.07] | 0.000 | 60.3 | 0.002 |