Skip to main content
. 2016 Nov 17;7(52):86675–86686. doi: 10.18632/oncotarget.13431

Figure 1. Proposed mechanism for cellular uptake of AuNP-miR-375 nanoparticles and characteristics of the NPs.

Figure 1

A. Schematic illustration of gold nanoparticles delivered miR-375 for replacement therapy in hepatocellular carcinoma (HCC). After being taken up by hepatoma cells, AuNP-miR-375 nanoparticles escape from endosome/lysosome and mature miR-375 is released to the cytoplasm. Released miR-375 acts on its target genes like AEG-1, YAP1, and ATG7, and suppresses tumor malignant phenotypes of HCC cells. B. The shape of AuNP and AuNP-miR-375 nanoparticles imaged by a transmission electron microscope (TEM). C. The stability of AuNPs in ultrapure water and phosphate buffered saline (PBS) under 4°C or room temperature (RT). The hydrodynamic diameters of AuNPs were measured 8 times during more than two months by dynamic light scattering (DLS). D. Absorbance specturm of AuNP and AuNP-miR-375 nanoparticles obtained using a UV-Vis spectrophotometer.