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. 2016 Nov 17;7(52):86695–86703. doi: 10.18632/oncotarget.13435

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Copyright: © 2016 Chen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. The expression of ZG16 was significantly downregulated in CRC, especially CRC with liver metastasis based on the gene expression profile dataset of GSE49355. B. Ingenuity Pathway Analysis (IPA) indicated that the function of a panel of genes which are highly correlated with the expression of ZG16 (r>0.8 using Pearson correlation analysis) are mainly related to CRC. C. The IPA analysis indicated that most of these CRC related genes were regulated by APC/CTNNB1 pathway.