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. 2016 Nov 17;7(52):86695–86703. doi: 10.18632/oncotarget.13435

Figure 6. miR-196a/ZG16 contributes tumor growth of stem-like CRCs in vivo.

Figure 6

A and B. The representative images and tumor volume of tumors that formed from pLenti-ZG16 stably transfected LGR5+ CRC cells grew significantly slower than those formed from pLenti-control transfected LGR5+ CRC cells. C and D. The representative images and tumor volume of tumors that formed from p-miR-196a stably transfected LGR5- CRC cells grew significantly faster than those formed from p-miR-control transfected LGR5- CRC cells. E. The representative images of immunohistochemical (IHC) staining of tumour tissues showed that the expression of ZG16 was significantly increased in the pLenti-ZG16 stably transfected LGR5+ CRC tumors, while significantly decreased in p-miR-196a stably transfected LGR5- CRC tumours.