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. 2016 Nov 17;7(52):86740–86754. doi: 10.18632/oncotarget.13436

Figure 8. Relative mRNA expression of Lgr6 in hairless A. and haired B. mice.

Figure 8

Gene expression of Lgr6 and Ki67 was measured by qPCR and normalized against stably expressed reference genes (see Material and Methods). RNA was isolated from hairless samples taken from untreated skin, hyperplastic skin induced by UV and UV-induced tumors (A). Lgr6 gene expression was significantly reduced in UV-induced tumors compared to the untreated and hyperplastic skin samples (p=0.004). RNA was also isolated from untreated skin, chemically induced hyperplastic skin and chemically induced tumors from shaven haired mice (B). Reduction of Lgr6 in chemically induced tumors compared to the untreated and hyperplastic skin was not significant (p=0.07). Error bars are SEMs.