Table 1. The Gene Ontology analysis on common down- and up-regulated genes.

Category (BP-5)	Name	p-value	Expression upon trabectedin
0000988	tissue development	0.000884	down
0009887	organ morphogenesis	0.001	down
0051969	regulation of transmission of nerve impulse	0.002	down
0031644	regulation of neurological system process	0.003	down
0043588	skin development	0.005	down
0010556	regulation of macromolecule biosynthetic process	0.00001	up
0045449	regulation of transcription	0.00003	up
0031326	regulation of cellular biosynthetic process	0.00004	up
0010468	regulation of gene expression	0.00005
0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0001	up
0045596	negative regulation of cell differentiation	0.003	up

BP-5: biological process level 5