Figure 2. Ctnnb1CA hep mice are characterized by severe cholestasis and qualitative changes in bile acid composition.

Ctnnb1^{CA hep} mice displayed significantly increased serum (A) and hepatic (B) bile acid levels. Expression of Cyp7a1 (C) was significantly increased in Ctnnb1^{CA hep} mice, whereas mRNA levels of Cyp27 (D) and Cyp8b1 (E) were decreased in livers with continuous β-catenin activation. The composition of the bile acid pool was altered in Ctnnb1^{CA hep} mice (F). The percentage of tauro-β-muricholic acid (β-TMCA, G) and β-muricholic acid (β-MCA, H) of the total bile acid pool was significantly increased in Ctnnb1^{CA hep} mice, whereas the percentage of taurine-conjugated cholic acid (TCA, I) and deoxycholic acid (TDCA, J) was decreased.