Figure 4. Cholestasis causes deregulation of compensatory bile acid transporters in intestines and kidneys of Ctnnb1CA hep mice.

Enterocytes in the terminal ileum of Ctnnb1^{CA hep} mice displayed significantly reduced mRNA levels of the bile acid handling transporters Asbt (A), Ostα and β (B) and Babp (C). Proximal convoluted tubule cells in kidneys of Ctnnb1^{CA hep} mice displayed significantly reduced mRNA levels of Asbt (D). In contrast, mRNA levels of Abcc2 and Abcc4 were increased in Ctnnb1^{CA hep} mice (E). Expression of Ostα and β were significantly reduced in kidneys of Ctnnb1^{CA hep} mice (F).