Skip to main content
. 2016 Nov 23;7(52):87091–87099. doi: 10.18632/oncotarget.13526

Figure 6. miR-595 promoted the sensitivity of HO8910PM cells to cisplatin and inhibited ovarian cancer cell proliferation, colony formation and invasion through targeting ABCB1.

Figure 6

(A) The mRNA expression of ABCB1 was increased in the HO8910PM cell after treated with the ABCB1 vector. (B) The protein expression of ABCB1 in the HO8910PM cell was determined by Western blot. (C) Overexpression of ABCB1 decreased the HO8910PM cell response to cisplatin. (D) Overexpression of ABCB1 decreased the SKOV-3 cell response to cisplatin. (E) Overexpression of ABCB1 increased SKOV-3 cell proliferation. (F) The responses of miR-595-overexpressing HO8910PM cells to cisplatin were decreased after transfected with the ABCB1 vector. (G) Ecotopic expression of ABCB1 promoted the HO8910PM cell proliferation. (H) Overexpression of ABCB1 increased miR-595-overexpressing HO8910PM cell proliferation. (I) The responses of miR-595-overexpressing SKOV-3 cells to cisplatin were decreased after transfected with the ABCB1 vector. (J) Overexpression of ABCB1 increased miR-595-overexpressing SKOV-3 cell proliferation. (K) Overexpression of ABCB1 increased the miR-595-overexpressing HO8910PM cells colony formation. The relative conoly number was shown in the right. (L) Overexpression of ABCB1 increased the miR-595-overexpressing SKOV-3 cells colony formation. The relative conoly number was shown in the right. (M) Overexpression of ABCB1 increased the miR-595-overexpressing HO8910PM cells invasion. The relative invasive cells were shown in the right. (N) Overexpression of ABCB1 increased the miR-595-overexpressing SKOV-3 cells invasion. The relative invasive cells were shown in the right. *p < 0.05, **p < 0.01 and ***p < 0.001.