Table 10. Gene-environment interaction.

Factors	β	S.E.	Wald χ2	OR (95%CI) a	P
rs1047840 × Smoking	0.428	0.093	21.020	1.534(1.278∼1.842)	0.000
rs1047840 × Alcohol Consumption	0.336	0.096	12.225	1.399(1.159∼1.689)	0.000
rs1047840 × HBV Infection	2.102	0.074	809.417	8.818(7.078∼9.456)	0.000
rs1047840 × HCC family history	0.229	0.235	0.949	1.257(0.793∼1.293)	0.330
rs1776148 × Smoking	0.424	0.093	20.652	1.527(1.272∼1.833)	0.000
rs1776148 × Alcohol Consumption	0.318	0.095	11.066	1.374(1.139∼1.657)	0.001
rs1776148 × HBV Infection	2.080	0.073	820.029	8.003(6.941∼9.288)	0.000
rs1776148 × HCC family history	0.236	0.223	1.022	1.266(0.801∼2.001)	0.312
rs3754093 × Smoking	0.421	0.103	16.756	1.524(1.245∼1.864)	0.000
rs3754093 × Alcohol Consumption	0.367	0.105	12.101	1.443(1.174∼1.775)	0.001
rs3754093 × HBV Infection	2.326	0.092	641.686	10.235(8.549∼12.253)	0.000
rs3754093 × HCC family history	0.186	0.269	0.477	1.204(0.711∼2.041)	0.490
rs4149867 × Smoking	0.462	0.124	13.852	1.587(1.244∼2.023)	0.000
rs4149867 × Alcohol Consumption	0.385	0.134	8.240	1.469(1.130∼1.910)	0.004
rs4149867 × HBV Infection	3.238	0.126	664.917	25.485(19.925∼32.597)	0.000
rs4149867 × HCC family history	0.391	0.340	1.324	1.478(0.760∼2.876)	0.250
rs4149963 × Smoking	0.610	0.149	16.769	1.840(1.374∼2.464)	0.000
rs4149963 × Alcohol Consumption	0.454	0.159	8.276	1.580(1.157∼2.158)	0.004
rs4149963 × HBV Infection	3.707	0.134	762.612	40.703(31.296∼52.965)	0.000
rs4149963 × HCC family history	0.350	0.401	0.760	1.419(0.646∼3.113)	0.383
rs1776181 × Smoking	0.497	0.110	20.283	1.644(1.324∼2.042)	0.000
rs1776181 × Alcohol Consumption	0.347	0.115	9.139	1.414(1.130∼1.771)	0.003
rs1776181 × HBV Infection	2.578	0.103	620.820	13.175(10.756∼16.137)	0.000
rs1776181 × HCC family history	0.372	0.316	1.384	1.450(0.781∼2.695)	0.239

^a: Adjusted by logistic regression for age, gender, nations, smoking, alcohol consumption, HBV infection, and HCC family history.