Table 3. 72h GI50 values for ALK inhibitors in NBLW and NBLW-R cells.
Cell Line | NBLW | NBLW-R | P-value |
---|---|---|---|
Crizotinib | 584.0 ± 41.6 nM | 494.2 ± 43.5 nM | 0.22 |
TAE-684 | 38.5 ± 3.9 nM | 30.2 ± 5.3 nM | 0.02 |
Alectinib | 488.5 ± 49.1 nM | 307.3 ± 18.3 nM | 0.02 |
PF-06463922 (Lorlatinib) | > 10 μM | 169.9 ± 20.6 nM | < 0.0001 |
Data represent n ≥ 3 ± SEM.