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. 2016 Nov 24;7(52):87323–87341. doi: 10.18632/oncotarget.13556

Figure 1. Cancers display even distribution of somatic mutations across the CIT gene and predominately over-express CIT mRNA.

Figure 1

A. CIT point mutations identified from the COSMIC database (gene ID: CIT_ENST00000261833) were categorized into types of mutations. The percentage each mutation type contributes is noted within each segment. B. CIT substitution missense mutations across the gene were calculated and mapped per 10 amino acids. A schematic representation of CIT-K is shown below the mutation histogram to visualise the location of the mutations. Phosphorylation sites identified from our laboratory and PhosphoSitePlus are listed below the CIT-K protein structure. S1948 is in bold and indicated by an asterisk to highlight that it was found mutated in the COSMIC database. CC, coiled coil; RBD, Rho/Rac binding domain; C1, cysteine-rich motif; PH, pleckstrin homology; CNH, Citron-NIK homology. C. CIT mRNA from cancerous tissue was datamined from the Oncomine™ database and compared against corresponding normal tissues to observe any over- or under-expression. All of the datasets on Oncomine™ were included in the analysis, whether they showed a significant (p < 0.001) difference in CIT mRNA expression or not. The bars show how many datasets showed either significant over- or under-expression, with the numbers above each bar indicating exactly how many of those datasets demonstrated a significant difference.