Table 3. Differentially expressed epilepsy-relate genes in ≥ 5 pairs of samples.
| Symbol | description | Epilepsy-Related Disorders |
|---|---|---|
| AQP1 | aquaporin 1 | refractory epilepsy/mesial temporal lobe sclerosis |
| ATF3 | activating transcription factor 3 | refractory mTLE |
| C3 | complement component 3 | TLE/FS/seizures following acute viral infection |
| CALB2 | calbindin 2 | TLE/FCD/LTP |
| CCR5 | chemokine (C-C motif) receptor 5 | refractory epilepsy/infantile-onset epilepsy/SUDEP/SE |
| EGR1 | early growth response 1 | IAE/focal epilepsy |
| EMP1 | epithelial membrane protein 1 | refractory epilepsy |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | West syndrome/FCD/TLE/anti-NMDAR encephalitis |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | IGE/JME/absence epilepsy |
| HP | haptoglobin | IGE/familial epilepsy |
| IL1A | interleukin 1, alpha | TLE/FS |
| IL1B | interleukin 1, beta | epilepsy |
| IL1RN | interleukin 1 receptor antagonist | TLE |
| IL6 | interleukin 6 | TLE/FS/familial epilepsy/refractory epilepsy |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | refractory epilepsy |
| IL18 | interleukin 18 | seizures in MS |
| ITGA2 | integrin, alpha 2 | refractory epilepsy |
| KCNA1 | potassium channel, voltage gated shaker related subfamily A, member 1 | SUDEP/TLE/partial epilepsy/Myokymia |
| NPY | neuropeptide Y | absence epilepsy/TLE/SE |
| OPRM1 | opioid receptor, mu 1 | tonic-clonic seizures/TLE/IGE/SE/IAE |
| PDYN | prodynorphin | TLE/FLTLE |
| RELN | reelin | TLE |
| PTGS2 | prostaglandin-endoperoxide synthase 2 | mTLE/absence seizures/poststroke seizures |
| SCN1B | sodium channel, voltage gated, type I beta subunit | Genetic GEFS+/Dravet Syndrome/convulsions with gastroenteritis/BPEI/LQTS/brugada syndrome |
| SCN5A | sodium channel, voltage gated, type V alpha subunit | Dravet syndrome/SUDEP/BFNS/LQTS/brugada syndrome |
| CCL2 | chemokine (C-C motif) ligand 2 | refractory epilepsy/SE |
| CCL4 | chemokine (C-C motif) ligand 4 | TLE |
| CDKL5 | cyclin-dependent kinase-like 5 | West syndrome/early-onset epileptic encephalopathies |
| CNTN2 | contactin 2 (axonal) | PME/Autosomal recessive epilepsy/Autoimmune epilepsy |
| TNF | tumor necrosis factor | TLE/refractory epilepsy |
| TRPC4 | transient receptor potential cation channel, subfamily C, member 4 | generalized epilepsy with photosensitivity |
| CACNA1H | calcium channel, voltage-dependent, T type, alpha 1H subunit | IGE/CAE/generalized epilepsy syndromes |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | early infantile epilepsy syndromes/malignant migrating partial seizures in infancy |
| ERMN | ermin, ERM-like protein | epileptic seizure/oligodendrocytes and epilepsy |
mTLE: mesial temporal lobe epilepsy; TLE: temporal lobe epilepsy; FS: febrile seizures; FCD: focal cortical dysplasia; LTP: long-term potentiation; SUDEP: sudden unexpected death in epilepsy; SE: status epilepticus; IAE: idiopathic absence epilepsy; IGE: idiopathic generalized epilepsy; JME: juvenile myoclonic epilepsy; MS: multiple sclerosis; FLTLE: familial lateral temporal lobe epilepsy; GEFS+: generalized epilepsy with febrile seizure plus; BPEI: benign partial epilepsy in infancy; LQTS: long QT syndrome; BFNS: benign familial neonatal seizure; PME: progressive myoclonic epilepsy; CAE: childhood absence epilepsy.