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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Pain. 2017 Apr;158(Suppl 1):S97–S107. doi: 10.1097/j.pain.0000000000000854

Figure 1. Contribution of sodium channel isoforms to action potential.

Figure 1

Based on their ability to boost subthreshold stimuli -- TTX-S channels Nav1.3 and Nav1.7 -- or hyperpolarized and persistent current -- TTX-R channel Nav1.9 -- these channels have been considered threshold channels for action potential firing. TTX-S channels Nav1.3, Nav1.6 (especially at nodes of Ranvier), and TTX-R channel Nav1.8 (in the neurons in which it is expressed), contribute most of the current for the action potential. Adapted with permission from [42]