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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Nat Rev Cardiol. 2016 Dec 22;14(4):238–250. doi: 10.1038/nrcardio.2016.203

Figure 1. Energy supply–demand matching in health and heart failure.

Figure 1

The delicate balance between cardiac demands for energy and supply of energy is tipped in heart failure, in which energy supply cannot match demand. Next-generation therapeutics can improve on existing standard-of-care therapies by bolstering mitochondrial energy production. ACE, angiotensin-converting enzyme; ARB, angiotensin II-receptor blocker; ETC, electron transport chain; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; ROS, reactive oxygen species.