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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: J Diabetes Complications. 2017 Jan 20;31(4):773–779. doi: 10.1016/j.jdiacomp.2016.12.010

Figure 1. Summary of the effects of tamoxifen.

Figure 1

Tamoxifen is an ER antagonist in breast and has estrogenic effects on bone and uterus. Tamoxifen decreases food intake, body weight and fat mass in rodents. It also lowers body weight in obese women. Tamoxifen decreases β-cell survival and proliferation in rodents and increases the incidence of diabetes in patients with breast cancer. Tamoxifen also promotes hepatic steatosis in rodents and women.