Table 3.

Associations between GPS derived from S4S meta-analysis results and ALSPAC alcohol outcomes.

Threshold	Consumption			Problems			Maxdrinks
	Beta	p-value	r2	Beta	p-value	r2	Beta	p-value	r2
p < 0.0001	0.0005	0.5844	0.0001	<0.0001	0.8548	<0.0001	0.0099	0.1127	0.0055
p < 0.001	<−0.0001	0.9379	<0.0001	<0.0001	0.6083	0.0001	0.0023	0.3009	<0.0001
p < 0.01	0.0002	0.0715	0.0013	0.0001	0.0088	0.0029	0.0011	0.2031	0.0037
p < 0.05	0.0002	0.0038	0.0037	<0.0001	0.0107	0.0022	0.0013	0.0050	0.0255
p < 0.10	0.0001	0.0093	0.0036	<0.0001	0.0960	0.0007	0.0011	0.0025	0.0675
p < 0.20	0.0001	0.0173	0.0028	<0.0001	0.1772	0.0007	0.0011	0.0008	0.0620
p < 0.30	0.0001	0.0148	0.0028	<0.0001	0.1070	0.0009	0.0010	0.0008	0.0649
p < 0.40	0.0001	0.0126	0.0029	<0.0001	0.1029	0.0011	0.0010	0.0007	0.0621
p < 0.50	0.0001	0.0114	0.0030	<0.0001	0.0985	0.0011	0.0010	0.0010	0.0533

Nagelkerke's r² is provided as a measure of variance accounted for by the polygenic score.