Figure 9.

Slc11a1⁺ mice are resistant to high-dose challenges of live vaccine strain (LVS) by the intranasal route. B6 [black lines (A–C)], Slc11a1⁺ [red lines (A)], Slc11a1⁺ Tlr2/4/9^−/− [blue lines (B)], or Slc11a1^± Tlr2^−/−/4^±/9^± [green lines (C)] mice were infected with the indicated doses of LVS via the intranasal route. Mice were monitored for survival and signs of disease. Significance was determined using a Mantel–Cox log rank test. N = 5 mice per group.