Figure 1.

Study design. Sixty-four C57BL/6 female mice were divided into two groups: control (CTRL, n = 32) received sterile saline (50 μL) intratracheally (i.t.), while silicosis group (SIL, n = 32) received silica particles (20 mg in 50 μL saline, i.t.). Fifteen days after disease induction, the animals were randomized to receive dimethyl sulfoxide (DMSO 1% in saline solution, 100 μL, oral gavage) or bosutinib (BOS 1 mg/kg body weight in DMSO 1%, 100 μL, oral gavage).