Table 2.
Protein | ASD |
Control |
p Value | ||
---|---|---|---|---|---|
Median | Interquartile range (IQR) | Median | IQR | ||
Activating | |||||
Unstimulated | |||||
Akt | 0.175 | 0.132 | 0.169 | 0.088 | 0.708 |
Mammalian target of rapamycin (mTOR) | 0.016 | 0.012 | 0.015 | 0.005 | 0.741 |
p70S6 kinase (p70S6K) | 0.250 | 0.092 | 0.221 | 0.094 | 0.406 |
Ribosomal protein S6 (RPS6) | 0.005 | 0.002 | 0.004 | 0.001 | 0.017 |
Extracellular receptor kinase (ERK) | 0.655 | 0.149 | 0.646 | 0.076 | 0.551 |
Stimulated (15 min) | |||||
Akt | 0.173 | 0.124 | 0.171 | 0.085 | 0.792 |
mTOR | 0.014 | 0.008 | 0.016 | 0.007 | 0.377 |
p70S6K | 0.263 | 0.110 | 0.265 | 0.109 | 0.474 |
RPS6 | 0.006 | 0.004 | 0.005 | 0.002 | 0.001 |
ERK | 0.604 | 0.196 | 0.605 | 0.155 | 0.669 |
Stimulated (45 min) | |||||
Akt | 0.168 | 0.107 | 0.169 | 0.090 | 0.853 |
mTOR | 0.018 | 0.008 | 0.016 | 0.009 | 0.071 |
p70S6K | 0.270 | 0.089 | 0.273 | 0.141 | 0.966 |
RPS6 | 0.014 | 0.016 | 0.009 | 0.008 | 0.003 |
ERK | 0.607 | 0.115 | 0.617 | 0.118 | 0.664 |
Inactivating | |||||
Unstimulated | |||||
Insulin receptor substrate-1 (IRS1) | 0.027 | 0.026 | 0.018 | 0.022 | 0.030 |
PTEN | 0.289 | 0.156 | 0.255 | 0.079 | 0.129 |
Glycogen synthase kinase 3 (GSK) 3α | 0.282 | 0.275 | 0.254 | 0.203 | 0.729 |
GSK3β | 0.269 | 0.238 | 0.260 | 0.130 | 0.544 |
TSC2 | 0.040 | 0.049 | 0.039 | 0.056 | 0.590 |
Stimulated (15 min) | |||||
IRS1 | 0.030 | 0.023 | 0.021 | 0.020 | 0.041 |
PTEN | 0.307 | 0.146 | 0.266 | 0.075 | 0.067 |
GSK3α | 0.209 | 0.245 | 0.280 | 0.214 | 0.053 |
GSK3β | 0.153 | 0.169 | 0.168 | 0.143 | 0.378 |
TSC2 | 0.043 | 0.050 | 0.036 | 0.056 | 0.538 |
Stimulated (45 min) | |||||
IRS1 | 0.040 | 0.028 | 0.024 | 0.031 | 0.004 |
PTEN | 0.284 | 0.114 | 0.245 | 0.074 | 0.078 |
GSK3α | 0.210 | 0.186 | 0.276 | 0.131 | 0.065 |
GSK3β | 0.115 | 0.109 | 0.159 | 0.128 | 0.147 |
TSC2 | 0.040 | 0.049 | 0.035 | 0.056 | 0.866 |
All p values were calculated with two-tailed Mann–Whitney U-tests.
Values in bold and gray shades signifies a p < 0.05.