Table 3.

Akt/mTOR pathway phosphorylated protein in T cells.

Protein	ASD		Control		p Value
	Median	Interquartile range (IQR)	Median	IQR
Activating
Unstimulated
Akt	0.006	0.004	0.005	0.003	0.110
Mammalian target of rapamycin (mTOR)	0.024	0.017	0.015	0.012	0.006
p70S6 kinase (p70S6K)	0.011	0.007	0.008	0.004	0.064
Ribosomal protein S6 (RPS6)	0.009	0.006	0.009	0.005	0.473
Extracellular receptor kinase (ERK)	0.006	0.004	0.006	0.002	0.211
Stimulated (15 min)
Akt	0.008	0.005	0.005	0.006	0.013
mTOR	0.099	0.088	0.057	0.088	0.011
p70S6K	0.093	0.142	0.027	0.125	0.018
RPS6	0.060	0.071	0.013	0.070	0.085
ERK	0.153	0.150	0.080	0.195	0.029
Stimulated (45 min)
Akt	0.008	0.005	0.005	0.005	0.006
mTOR	0.127	0.094	0.071	0.107	0.002
p70S6K	0.142	0.140	0.069	0.145	0.003
RPS6	0.137	0.221	0.035	0.200	0.023
ERK	0.104	0.094	0.043	0.103	0.005
Inactivating
Unstimulated
Insulin receptor substrate-1 (IRS1)	0.005	0.004	0.004	0.003	0.064
PTEN	0.219	0.097	0.170	0.074	0.000
Glycogen synthase kinase 3 (GSK3)α	0.015	0.012	0.011	0.005	0.002
GSK3β	0.023	0.021	0.012	0.014	0.000
TSC2	0.016	0.012	0.013	0.006	0.001
Stimulated (15 min)
IRS1	0.009	0.007	0.004	0.008	0.009
PTEN	0.208	0.119	0.175	0.111	0.045
GSK3α	0.317	0.326	0.161	0.361	0.009
GSK3β	0.116	0.099	0.064	0.118	0.023
TSC2	0.052	0.039	0.034	0.054	0.027
Stimulated (45 min)
IRS1	0.010	0.016	0.005	0.006	0.003
PTEN	0.233	0.176	0.164	0.050	0.001
GSK3α	0.307	0.303	0.107	0.263	0.001
GSK3β	0.113	0.077	0.067	0.089	0.002
TSC2	0.054	0.046	0.028	0.039	0.000

Median and IQR of phosphorylated Akt/mTOR pathway proteins. All p values were calculated with two-tailed Mann-Whitney U-tests.

Values in bold and gray shades signifies a p < 0.05.