Table 4.
Protein | ASD |
Control |
p Value | ||
---|---|---|---|---|---|
Median | Interquartile range (IQR) | Median | IQR | ||
Activating | |||||
Unstimulated | |||||
Akt | 0.039 | 0.050 | 0.028 | 0.021 | 0.544 |
Mammalian target of rapamycin (mTOR) | 1.262 | 1.529 | 0.941 | 0.866 | 0.024 |
p70S6 kinase (p70S6K) | 0.041 | 0.038 | 0.035 | 0.019 | 0.254 |
Ribosomal protein S6 (RPS6) | 1.685 | 1.532 | 1.995 | 1.395 | 0.590 |
Extracellular receptor kinase (ERK) | 0.009 | 0.009 | 0.009 | 0.004 | 0.597 |
Stimulated (15 min) | |||||
Akt | 0.053 | 0.046 | 0.039 | 0.038 | 0.129 |
mTOR | 5.954 | 6.491 | 2.770 | 5.730 | 0.016 |
p70S6K | 0.342 | 0.653 | 0.104 | 0.357 | 0.002 |
RPS6 | 5.787 | 7.306 | 3.298 | 10.334 | 0.274 |
ERK | 0.227 | 0.288 | 0.127 | 0.367 | 0.027 |
Stimulated (45 min) | |||||
Akt | 0.062 | 0.058 | 0.036 | 0.042 | 0.078 |
mTOR | 6.769 | 6.872 | 3.929 | 5.815 | 0.008 |
p70S6K | 0.503 | 0.588 | 0.225 | 0.417 | 0.004 |
RPS6 | 9.008 | 8.853 | 4.325 | 17.095 | 0.087 |
ERK | 0.178 | 0.168 | 0.078 | 0.186 | 0.050 |
Inactivating | |||||
Unstimulated | |||||
Insulin receptor substrate-1 (IRS1) | 0.235 | 0.294 | 0.250 | 0.224 | 0.346 |
PTEN | 0.681 | 0.461 | 0.647 | 0.278 | 0.115 |
Glycogen synthase kinase 3 (GSK3)α | 0.072 | 0.283 | 0.043 | 0.090 | 0.057 |
GSK3β | 0.073 | 0.111 | 0.050 | 0.042 | 0.010 |
TSC2 | 0.428 | 2.717 | 0.360 | 1.653 | 0.153 |
Stimulated (15 min) | |||||
IRS1 | 0.305 | 0.695 | 0.275 | 0.347 | 0.834 |
PTEN | 0.680 | 0.452 | 0.673 | 0.276 | 0.636 |
GSK3α | 1.409 | 6.295 | 0.505 | 1.964 | 0.004 |
GSK3β | 0.808 | 0.921 | 0.484 | 0.969 | 0.055 |
TSC2 | 1.797 | 7.840 | 0.867 | 2.747 | 0.039 |
Stimulated (45 min) | |||||
IRS1 | 0.232 | 0.374 | 0.254 | 0.352 | 0.874 |
PTEN | 0.860 | 0.445 | 0.663 | 0.207 | 0.025 |
GSK3α | 1.199 | 4.969 | 0.364 | 1.290 | 0.004 |
GSK3β | 0.977 | 0.783 | 0.523 | 0.899 | 0.017 |
TSC2 | 1.548 | 5.008 | 0.786 | 1.909 | 0.029 |
Median and IQR of phosphorylated/total Akt/mTOR pathway proteins. All p values were calculated with two-tailed Mann–Whitney U-tests.
Values in bold and gray shades signifies a p < 0.05.