Table 4.

Akt/mTOR pathway phosphorylated/total protein ratios in T cells.

Protein	ASD		Control		p Value
	Median	Interquartile range (IQR)	Median	IQR
Activating
Unstimulated
Akt	0.039	0.050	0.028	0.021	0.544
Mammalian target of rapamycin (mTOR)	1.262	1.529	0.941	0.866	0.024
p70S6 kinase (p70S6K)	0.041	0.038	0.035	0.019	0.254
Ribosomal protein S6 (RPS6)	1.685	1.532	1.995	1.395	0.590
Extracellular receptor kinase (ERK)	0.009	0.009	0.009	0.004	0.597
Stimulated (15 min)
Akt	0.053	0.046	0.039	0.038	0.129
mTOR	5.954	6.491	2.770	5.730	0.016
p70S6K	0.342	0.653	0.104	0.357	0.002
RPS6	5.787	7.306	3.298	10.334	0.274
ERK	0.227	0.288	0.127	0.367	0.027
Stimulated (45 min)
Akt	0.062	0.058	0.036	0.042	0.078
mTOR	6.769	6.872	3.929	5.815	0.008
p70S6K	0.503	0.588	0.225	0.417	0.004
RPS6	9.008	8.853	4.325	17.095	0.087
ERK	0.178	0.168	0.078	0.186	0.050
Inactivating
Unstimulated
Insulin receptor substrate-1 (IRS1)	0.235	0.294	0.250	0.224	0.346
PTEN	0.681	0.461	0.647	0.278	0.115
Glycogen synthase kinase 3 (GSK3)α	0.072	0.283	0.043	0.090	0.057
GSK3β	0.073	0.111	0.050	0.042	0.010
TSC2	0.428	2.717	0.360	1.653	0.153
Stimulated (15 min)
IRS1	0.305	0.695	0.275	0.347	0.834
PTEN	0.680	0.452	0.673	0.276	0.636
GSK3α	1.409	6.295	0.505	1.964	0.004
GSK3β	0.808	0.921	0.484	0.969	0.055
TSC2	1.797	7.840	0.867	2.747	0.039
Stimulated (45 min)
IRS1	0.232	0.374	0.254	0.352	0.874
PTEN	0.860	0.445	0.663	0.207	0.025
GSK3α	1.199	4.969	0.364	1.290	0.004
GSK3β	0.977	0.783	0.523	0.899	0.017
TSC2	1.548	5.008	0.786	1.909	0.029

Median and IQR of phosphorylated/total Akt/mTOR pathway proteins. All p values were calculated with two-tailed Mann–Whitney U-tests.

Values in bold and gray shades signifies a p < 0.05.