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Effect of phosphorylation on target sites of Akt/mTOR pathway proteins.
| Activating | Inactivating | ||
|---|---|---|---|
| Akt | Ser473 | IRS1 | Ser312 |
| mTOR | Ser2448 | PTEN | Ser380 |
| p70S6K | Thr412 | GSK3α | Ser21 |
| RPS6 | Ser235/Ser236 | GSK3β | Ser9 |
| ERK | Thr185/Tyr187 | TSC2 | Ser939 |
Proteins are organized according to whether the effect of phosphorylation on a specific phosphorylation site is activating or inactivating. The sites listed in the table are those measured in this article.
