Table 1.

Effect of 10 μmol/L NS5806 on action potentials from rabbit ventricular and atrial myocytes

	Ventricular cells (n = 7)		Atrial cells (n = 7)
	Control	10 μmol/L NS5806	Control	10 μmol/L NS5806
Overshoot (mV)	56.0 ± 2.0	54.8 ± 2.0	43.5 ± 3.2	−2.3 ± 4.4 b
AP amplitude (mV)	137.5 ± 1.9	137.0 ± 2.0	123.2 ± 2.8	73.9 ± 3.8 b
Upstroke velocity (mV/msec) (percentage change,%)	128.4 ± 8.6	134.3 ± 7.0	120.9 ± 8.3	27.4 ± 4.9 b(−77.4 ± 3.8)
APD20 (msec) (percentage change,%)	73.6 ± 8.0	46.0 ± 4.9 b (−36.5 ± 5.0)	8.2 ± 1.1	16.0 ± 2.8 b(90.9 ± 14.7)
APD50 (msec) (percentage change,%)	133.8 ± 8.4	91.6 ± 6.4 b (−31.2 ± 3.3)	18.0 ± 2.8	32.9 ± 5.8 b(88.6 ± 18.8)
APD90 (msec) (percentage change,%)	167.4 ± 9.7	125.9 ± 8.8 b (−24.7 ± 3.0)	101.8 ± 7.3	128.6 ± 5.9 a(30.7 ± 12.0)

^a P < 0.05.

^b P < 0.01, paired t‐test.