Table 2.
Comparison of effects of NS5806 on normal rabbit and dog ventricular Ito
| Ito property | Rabbit | Source | Dog | Reference |
|---|---|---|---|---|
| Ventricle | ||||
| Current amplitude |
Initial: ↑ EC50 1.6 μmol/L Steady state: “bell‐shaped” EC50 1.6 μmol/L; IC50 40 μmol/L |
This study |
↑ at 10 μmol/L ↑ at 10 μmol/L (Epi by 80%, Mid by 82% Endo by 16%) |
Calloe et al. 2009
Calloe et al. 2010, 2011 |
| Voltage dependence of activation | Negative shift in V0.5 of ~ −29 mV | This study | No data | |
| Time course of inactivation | Accelerated: thalf at +40 mV decreased from 30.3 msec to 21.5 msec (by 29%) | This study |
Slowed: Tau at +40 mV increased from 12.6 to 20.3 ms (by 61%) Ito integral increased to 227%, 192% and 83% of control in EPI, MID and EPI |
Calloe et al. 2009
Calloe et al. 2010; |
| Voltage dependence of inactivation | No statistical difference | This study | Negative shift in V0.5 of −6 mV EPI, −5 mV MID, −3.4 ENDO | Calloe et al. 2010 Calloe et al. 2011 |
| Restitution | Accelerated: tau from 2417 msec to 1814 msec (by ~25%) | This study | Accelerated EPI and MID and biexponential to single exponential time course |
Calloe et al. 2009
Calloe et al. 2010 |