Table 3.
Comparison of effects of NS5806 on normal rabbit and dog atrial Ito
| Ito property | Rabbit | Source | Dog | Reference |
|---|---|---|---|---|
| Atrium | ||||
| Current amplitude | ↓ IC50 18.2 μmol/L | This study | ↑ at 10 μmol/L (25%) | Calloe et al. 2011 |
| Voltage dependence of activation | Negative shift in V0.5 of ~ 11 mV | This study | No data | |
| Time course of inactivation | Slowed: thalf at +40 mV increased from 13.5 msec to 17.3 msec (by 28%) | This study | Slowed: Tau at +50 mV increased from 20 to 26.5 ms (by 32.5%) | Calloe et al. 2011 |
| Voltage dependence of inactivation | Negative shift in V0.5 of ~ ‐3.3 mV | This study | Negative shift in V0.5 of ‐7.3 mV | Calloe et al. 2011 |
| Restitution | No significant change | This study | Accelerated and biexponential changed to single exponential time course | Calloe et al. 2011 |