Table 2.

Mixed model based on SHIFT patient-level data (with treatment interaction)

Description	Coefficient	SE	p value	95% LCI	95% UCI
Treatment	0.0104	0.0047	0.0270	0.0012	0.0195
Age (years)a	−0.0008	0.0002	0.0000	−0.0012	−0.0004
Female	−0.0590	0.0057	0.0000	−0.0702	−0.0478
Hospitalization within 30 days	−0.2116	0.0320	0.0000	−0.2744	−0.1489
NYHA II	−0.0848	0.0089	0.0000	−0.1023	−0.0673
NYHA III	−0.1798	0.0094	0.0000	−0.1982	−0.1614
NYHA IV	−0.3656	0.0182	0.0000	−0.4012	−0.3300
Ischemia	−0.0365	0.0054	0.0000	−0.0471	−0.0258
Stroke	−0.0243	0.0086	0.0050	−0.0410	−0.0075
HF duration ≥0.6, <2 years	−0.0191	0.0067	0.0040	−0.0322	−0.0061
HF duration ≥2, <4.8 years	−0.0394	0.0068	0.0000	−0.0526	−0.0262
HF duration ≥4.8 years	−0.0456	0.0068	0.0000	−0.0590	−0.0322
Allopurinol	0.0220	0.0098	0.0260	0.0027	0.0413
BMI kg/m2a	−0.0026	0.0005	0.0000	−0.0035	−0.0016
Heart rate (bpm)a	−0.0021	0.0004	0.0000	−0.0028	−0.0014
Loop diuretics dose/kg/day	−0.0158	0.0032	0.0000	−0.0220	−0.0096
Potassium >5 mmol/L	−0.0142	0.0060	0.0190	−0.0261	−0.0023
Hosp30 × NYHA I	0.1403	0.0832	0.0920	−0.0228	0.3035
Hosp30 × NYHA II	0.1792	0.0352	0.0000	0.1102	0.2482
Hosp30 × NYHA III	0.1281	0.0344	0.0000	0.0607	0.1955
Treatment × heart rate	0.0008	0.0005	0.1330	−0.0002	0.0017
Cons	0.9082	0.0108	0.0000	0.8870	0.9293

LCI lower confidence interval, UCI upper confidence interval, NYHA New York Heart Association, HF heart failure, BMI body mass index, SE standard error

^aVariables centered on the mean