Table 2. Comparison of eyes with and without pRNFL thinning in patients with optic neuritis.
| Variables | Thinning (−) (n=12) | Thinning (+) (n=21) | P-value |
|---|---|---|---|
| Age (year) | 50.83±16.22 | 43.05±17.27 | 0.129 |
| Sex (M/F) | 2 : 10 | 10 : 11 | 0.133 |
| Initial color vision abnormality, n (%) | 7 (58) | 15 (71) | 0.471 |
| Retrobulbar ON, n (%) | 2 (17) | 8 (38) | 0.259 |
| Abnormal optic nerve thickening or enhancement on MRI, n (%) | 5 (42) | 16 (76) | 0.067 |
| Elapsed period from onset of visual symptoms to steroid treatment (days) | 8.73±3.82 | 9.95±7.17 | 0.829 |
| Visual acuity (logMAR) | |||
| Initial | 0.41±0.46 | 1.53±1.26 | 0.019 |
| Final | 0.05±0.06 | 0.31±0.69 | 0.699 |
| Visual field (MD) | |||
| Initial | −11.05±4.56 | −21.35±10.48 | 0.011 |
| Final | −2.09±1.51 | −6.63±9.18 | 0.030 |
| Final visual field abnormality, n (%) | 0 (0%) | 11 (52%) | 0.002 |
| pRNFL (average) | |||
| Initial | 170.08±58.05 | 148.33±58.03 | 0.254 |
| Intereye differencea | 38.83±27.27 | 42.86±33.58 | 0.534 |
| Final | 101.25±10.04 | 69.81±10.88 | <0.001 |
| Intereye differencea | 8.0±11.73 | −21.14±16.39 | 0.045 |
| GCIPL (average GCL+IPL) | |||
| Initial | 80.57±5.56 | 78.75±4.91 | 0.376 |
| Intereye differencea | 0±7.32 | −1.0±4.90 | 0.534 |
| Final | 75.29±6.78 | 63.14±8.64 | 0.004 |
| Intereye differencea | −7.5±12.91 | −17.0±10.0 | 0.234 |
Abbreviations: pRNFL, peripapillary retinal nerve fiber layer; n, number; logMAR, logarithm of the minimum angle of resolution; MD, mean deviation; GCIPL, ganglion cell-inner plexiform layer; GCL, ganglion cell layer; IPL: inner plexiform layer.
a
The difference was calculated by subtracting the value of the eye without optic neuritis from that of the eye with optic neuritis.