Table 3. Comparison of eyes with and without GCIPL thinning in patients with optic neuritis.
| Variables | Thinning (−) (n=8) | Thinning (+) (n=25) | P-value |
|---|---|---|---|
| Age (year) | 54.75±16.25 | 43.04±16.64 | 0.055 |
| Sex (M/F) | 1 : 7 | 11 : 14 | 0.206 |
| Initial color vision abnormality, n (%) | 6 (75) | 16 (64) | 0.687 |
| Retrobulbar ON, n (%) | 2 (25) | 8 (32) | 1.000 |
| Abnormal optic nerve thickening or enhancement on MRI, n (%) | 3 (38) | 18 (72) | 0.106 |
| Elapsed period from onset of visual symptoms to steroid treatment (days) | 6.88±2.23 | 10.45±6.80 | 0.202 |
| Visual acuity (logMAR) | |||
| Initial | 0.54±0.52 | 1.31±1.26 | 0.352 |
| Final | 0.06±0.07 | 0.26±0.64 | 0.984 |
| Visual field (MD) | |||
| Initial | −10.53±4.91 | −19.87±10.28 | 0.025 |
| Final | −2.10±2.04 | −5.81±8.60 | 0.204 |
| Final visual field abnormality, n (%) | 0 (0%) | 10 (40%) | 0.071 |
| pRNFL (average) | |||
| Initial | 171.38±66.10 | 151.40±55.90 | 0.522 |
| Intereye differencea | 33.67±25.15 | 43.20±27.33 | 0.217 |
| Final | 105.25±10.15 | 73.56±13.26 | <0.001 |
| Intereye differencea | 16.0±26.15 | −15.0±17.0 | 0.077 |
| GCIPL (average GCL+IPL) | |||
| Initial | 83.67±3.84 | 79.32±4.27 | 0.108 |
| Intereye differencea | 6.0±2.65 | −2.50±3.10 | 0.287 |
| Final | 81.67±4.28 | 64.32±8.48 | <0.001 |
| Intereye differencea | 3.66±2.52 | −17.0±9.0 | 0.007 |
Abbreviations: GCIPL, ganglion cell-inner plexiform layer; n, number; logMAR, logarithm of the minimum angle of resolution; MD, mean deviation; pRNFL, peripapillary retinal nerve fiber layer; GCL, ganglion cell layer; IPL: inner plexiform layer.
a
The difference was calculated by subtracting the value of the eye without optic neuritis from that of the eye with optic neuritis.