Table 5. Factors associated with pRNFL and GCIPL thinning in optic neuritis patients.
| Variables |
Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| Odd ratio (95% CI) | P-value | Odd ratio (95% CI) | P-value | |
| pRNFL thinning | ||||
| Age | 0.972 (0.930–1.016) | 0.209 | ||
| Sex (male) | 4.545 (0.795–25.976) | 0.089 | 8.694 (0.854–88.507) | 0.068 |
| Initial color vision abnormality | 1.786 (0.403–7.906) | 0.445 | ||
| Abnormal optic nerve thickening or enhancement on MRI | 4.480 (0.975–20.585) | 0.054 | 1.497 (0.098–22.923) | 0.772 |
| Elapsed period from onset of visual symptoms to steroid treatment (day) | 1.036 (0.909–1.181) | 0.594 | ||
| Initial visual acuity (logMAR) | 4.032 (1.146–14.185) | 0.030 | 1.750 (0.329–9.303) | 0.512 |
| Initial visual field (MD) | 0.870 (0.781–0.968) | 0.011 | 0.841 (0.730–0.970) | 0.017 |
| Initial average pRNFL thickness (μm) | 0.993 (0.981–1.006) | 0.302 | ||
| Initial average GCIPL thickness (μm) | 0.921 (0.754–1.126) | 0.424 | ||
| Final visual acuity (logMAR) | 15.490 (0.034–7022.247) | 0.380 | ||
| Final visual field (MD) | 0.666 (0.428–1.036) | 0.071 | 0.630 (0.386–1.026) | 0.063 |
| Initial intereye average pRNFL asymmetry | 0.997 (0.989–1.005) | 0.507 | ||
| Initial intereye average GCIPL asymmetry | 1.008 (0.987–1.029) | 0.477 | ||
| GCIPL thinning | ||||
| Age | 0.943 (0.885–1.005) | 0.069 | 0.936(0.869–1.007) | 0.077 |
| Sex (male) | 5.500 (0.586–51.620) | 0.136 | ||
| Initial color vision abnormality | 0.593 (0.098–3.573) | 0.273 | ||
| Abnormal optic nerve thickening or enhancement on MRI | 4.286 (0.801–22.197) | 0.089 | 0.850 (0.078–9.263) | 0.894 |
| Elapsed period from onset of visual symptoms to steroid treatment (day) | 1.143 (0.949–1.375) | 0.159 | ||
| Initial visual acuity (logMAR) | 2.234 (0.782–6.379) | 0.133 | ||
| Initial visual field (MD) | 0.878 (0.776–0.993) | 0.039 | 0.871 (0.761–0.998) | 0.046 |
| Initial average pRNFL thickness (μm) | 0.994 (0.981–1.008) | 0.397 | ||
| Initial average GCIPL thickness (μm) | 0.637 (0.337–1.206) | 0.166 | ||
| Final visual acuity (logMAR) | 4.953 (0.050–491.929) | 0.495 | ||
| Final visual field (MD) | 0.769 (0.510–1.160) | 0.211 | ||
| Initial intereye average pRNFL asymmetry | 0.997 (0.988–1.006) | 0.484 | ||
| Initial intereye average GCIPL asymmetry | 1.051 (0.968–1.140) | 0.234 | ||
Abbreviations: pRNFL, peripapillary retinal nerve fiber layer; GCIPL, ganglion cell-inner plexiform layer; CI, confidence interval; logMAR, logarithm of the minimum angle of resolution; MD, mean deviation.
Factors with statistical significance are shown in bold.