Table 1.
Characteristics after 4 and 8 weeks of diet intervention without sevoflurane exposure.
| 4 weeks | 8 weeks | ||||
|---|---|---|---|---|---|
| Control diet | Western diet | Control diet | Western diet | Reversion | |
| Caloric intake [kcal/100 gBW] | 139 ± 9 | 145 ± 11 | 125 ± 6 | 128 ± 8 | 115 ± 6# |
| Plasma glucose [mmol/L] | 7.0 ± 0.6 | 7.4 ± 0.8 | 8.7 ± 0.7 | 10.5 ± 1.0∗ | 8.2 ± 1.2# |
| Plasma insulin [pmol/L] | 400 ± 142 | 691 ± 205∗ | 1029 ± 291 | 1529 ± 381∗ | 813 ± 369# |
| Plasma free fatty acids [mmol/L] | 0.90 ± 0.18 | 1.00 ± 0.16 | 0.28 ± 0.10 | 0.43 ± 0.09 | 0.28 ± 0.11 |
| Plasma triglycerides [mmol/L] | 0.92 ± 0.21 | 2.04 ± 0.72∗ | 0.71 ± 0.16 | 3.36 ± 1.28∗ | 0.76 ± 0.28# |
| Plasma HDL cholesterol [mg/dL] | 71.0 ± 3.0 | 39.9 ± 9.0∗ | 115.7 ± 7.5 | 62.5 ± 7.0∗ | 109.3 ± 12.5# |
| Plasma LDL/VLDL cholesterol [mg/dL] | 12.4 ± 2.7 | 10.2 ± 4.2 | 16.2 ± 1.7 | 25.7 ± 5.7∗ | 18.0 ± 2.8# |
| Hematocrit [%] | 48.3 ± 2.8 | 47.2 ± 2.9 | 51.6 ± 2.8 | 48.1 ± 2.6∗ | 49.0 ± 1.3 |
| Bodyweight [g] | 368 ± 13 | 409 ± 6∗ | 419 ± 15 | 476 ± 26∗ | 433 ± 30# |
| Heart weight [g] | n.d. | n.d. | 1.20 ± 0.06 | 1.34 ± 0.16∗ | 1.29 ± 0.07 |
| Liver weight [g] | n.d. | n.d. | 11.0 ± 0.5 | 14.2 ± 1.1∗ | 11.2 ± 2.2# |
| Epididymal fat weight [g] | n.d. | n.d. | 6.3 ± 0.3 | 11.4 ± 2.2∗ | 7.4 ± 1.6# |
| Perirenal fat weight [g] | n.d. | n.d. | 8.5 ± 0.4 | 16.3 ± 3.9∗ | 9.4 ± 1.9# |
| Tibia length [mm] | n.d. | n.d. | 42.0 ± 0.5 | 41.8 ± 1.1 | 41.3 ± 1.1 |
Data are mean ± SD, n = 7,4 weeks: Student's t-test, ∗p < 0.05 versus control diet; 8 weeks: one-way ANOVA with Bonferroni post hoc test, ∗p < 0.05 versus control diet, #p < 0.05 versus western diet, and n.d.: nondetermined.