Table 2.
Myocardial function after 4 and 8 weeks of diet intervention without sevoflurane exposure.
| 4 weeks | 8 weeks | ||||
|---|---|---|---|---|---|
| Control diet | Western diet | Control diet | Western diet | Reversion | |
| Heart rate [bpm] | 465 ± 39 | 486 ± 28 | 431 ± 26 | 489 ± 18∗ | 474 ± 16 |
| LV mass [mg] | 786 ± 95 | 840 ± 46 | 846 ± 114 | 936 ± 72 | 816 ± 58# |
| LV dimensions | |||||
| Diastolic lumen diameter [mm] | 6.6 ± 0.4 | 6.1 ± 0.4∗ | 6.6 ± 0.5 | 5.9 ± 0.3∗ | 6.1 ± 0.5 |
| Systolic lumen diameter [mm] | 1.7 ± 0.2 | 2.8 ± 0.3∗ | 2.1 ± 0.3 | 2.5 ± 0.3ǂ | 1.7 ± 0.3# |
| Diastolic wall thickness [mm] | 1.7 ± 0.1 | 2.0 ± 0.1∗ | 1.7 ± 0.1 | 2.2 ± 0.2∗ | 1.9 ± 0.2# |
| Systolic wall thickness [mm] | 3.7 ± 0.2 | 3.4 ± 0.2∗ | 3.7 ± 0.2 | 3.6 ± 0.1 | 3.8 ± 0.2 |
| LV diastolic function | |||||
| E deceleration time [ms] | 23.9 ± 7.4 | 31.0 ± 4.9ǂ | 25.0 ± 2.7 | 30.2 ± 5.4∗ | 23.4 ± 6.3# |
| Isovolumic relaxation time [ms] | 13.8 ± 2.3 | 20.3 ± 4.2∗ | n.d. | n.d. | n.d. |
Data are mean ± SD, n = 7 and 4 weeks: Student's t-test, ∗p < 0.05 versus control diet, ǂp = 0.06 versus control diet; 8 weeks: one-way ANOVA with Bonferroni post hoc analyses; ∗p < 0.05 versus control diet, ǂp = 0.06 versus control diet, and #p < 0.05 versus western diet. LV: left ventricular.