Figure 10. Effect of basolateral and apical H⁺,K⁺‐ATPase activity on key variables in the secreting duct model.

Steady‐state values in the stimulated condition of intracellular pH (pH_c) (A), secretory volume flow (J _v) (B), and secreted HCO₃ ⁻ concentration ([HCO₃ ⁻]_l) (C) for a range of basolateral and apical H⁺,K⁺‐ATPase activities (G _HK). Curves are plotted against basolateral G _HK (abscissa) for three different apical G _HK values: 10⁻¹⁰ (filled circles), 10⁻⁸ (open circles) and 10⁻⁷ mol s⁻¹ cm⁻² (open squares). The Cl⁻:HCO₃ ⁻ stoichiometry of the SLC26A6 exchanger was assumed to be 1:2.