Table 7.
Steady‐state values of variables in the secreting duct model in resting and stimulated conditions for the alternative 1:2 and 1:1 stoichiometries of SLC26A6
| Resting | Stimulated | |||
|---|---|---|---|---|
| 1:2 | 1:1 | 1:2 | 1:1 | |
| Lumen | ||||
| [K+]l (mm) | 5.4 | 5.4 | 5.5 | 5.5 |
| [Na+]l (mm) | 150.0 | 150.0 | 151.6 | 151.6 |
| [Cl–]l (mm) | 80.8 | 93.3 | 17.5 | 17.3 |
| [HCO3 –]l (mm) | 74.7 | 62.1 | 139.6 | 139.8 |
| Osm l (mOsm) | 310.9 | 310.9 | 314.2 | 314.2 |
| pHl | 7.90 | 7.83 | 8.17 | 8.17 |
| E tj (mV) | −3.4 | −3.4 | −4.8 | −4.8 |
| Cell | ||||
| [K+]c (mm) | 127.2 | 126.8 | 121.3 | 120.8 |
| [Na+]c (mm) | 9.0 | 9.5 | 11.6 | 12.2 |
| [Cl–]c (mm) | 21.3 | 23.3 | 2.4 | 2.4 |
| [HCO3 –]c (mm) | 22.4 | 21.9 | 21.5 | 21.4 |
| [X]c (mm) | 126.4 | 124.9 | 149.7 | 149.8 |
| Osm c (mOsm) | 306.3 | 306.3 | 306.5 | 306.5 |
| pHc | 7.37 | 7.36 | 7.35 | 7.35 |
| V c (μl cm−2) | 1.05 | 1.06 | 0.96 | 0.96 |
| E bl (mV) | −69.5 | −68.9 | −72.6 | −71.7 |
| Interspace | ||||
| [K+]i (mm) | 5.0 | 5.0 | 5.0 | 5.0 |
| [Na+]i (mm) | 140.0 | 140.0 | 140.0 | 140.0 |
| [Cl−]i (mm) | 124.0 | 124.0 | 124.2 | 124.2 |
| [HCO3 −]i (mm) | 24.9 | 25.0 | 24.8 | 24.8 |
| [X]i (mm) | 12.0 | 12.0 | 12.0 | 12.0 |
| Osm i (mOsm) | 306.0 | 306.0 | 306.0 | 306.0 |
| pHi | 7.41 | 7.41 | 7.41 | 7.42 |
| V i (μl cm−2) | 0.011 | 0.011 | 0.011 | 0.011 |
| P i (10−5 cmH2O) | −1.2 | −1.2 | −2.0 | −2.0 |