Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Mar 6;216(3):675–693. doi: 10.1083/jcb.201607019

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Schatton et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 2. — Protein and transcript levels of a subset of nuclear-encoded mitochondrial proteins are down-regulated in Cluh^−/− livers. (A) Volcano plot of proteomics analyses of livers of E18.5 KO mice compared with WT. Names are indicated for all proteins relevant in the following experiments. Blue dots are mitochondrial proteins according to Mitocarta 2.0; gray dots indicate nonmitochondrial proteins. (B) Correlation of the abundance of significantly down-regulated proteins (FC ≥1.5) with corresponding transcript levels. Previously identified CLUH targets (Gao et al., 2014) are indicated in blue. The black line shows correlation regression of all genes. The black box shows statistics for all genes, and the blue box shows statistics only for identified CLUH targets. Names are indicated for genes for which mRNA stability is measured in the following experiments. The dashed line marks an RNA FC of 1. (C) Significantly enriched pathways highlighted by proteomics (blue) and transcriptomics (orange) data. (D) Disease implication analysis of proteomics data. In C and D, bars indicate log of p-values.