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Class Effects of Psychoactive Drugs
| Effects | TCAs | SSRIs | SNRIs |
|---|---|---|---|
| Peripheral pain modulation | ++ | ? | ++ |
| Central pain modulation | +++ | ? + | +++ |
| Motility | ++ | + | ? |
| Global well being | +++ | +++ | +++ |
| Pain | +++ | ? | +++ (no studies yet on visceral pain) |
| Psychiatric comorbidities | ++ (+++ full doses) | +++ | +++ |
SNRIs = serotonin norepinephrine reuptake inhibitors; SSRIs = selective serotonin reuptake inhibitor; TCAs = tricyclic antidepressant.
