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. 2017 Feb 9;19(3):193–198. doi: 10.1021/acscombsci.7b00009

Table 2. Screening of Acidic Conditions for Post-cyclization.

      yield (%)a
entry acid, solvent amount, time 6a 7a
1 TFA, MeOH 2 equiv., 18 h 10 traces
2 6 M aq. HCl 5 mL, 18 h 33 traces
3 acetyl chloride, MeOH 2 equiv., 18 h 36 5
4 2 M HCl in MeOH 5 mL, 4 h 64 6
a

Isolated yield.