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. 2004 Dec 15;114(12):1741–1751. doi: 10.1172/JCI18058

Figure 6.

Figure 6

RAGE–/– mice are partly protected from diabetes-induced loss of pain perception, but not from diabetes-induced loss of PGP9.5-positive plantar nerves. (A) Immunohistochemical reaction of small fibers in footpad skin of WT and RAGE–/– mice with the neuronal marker gene product PGP9.5. The number of mice studied was 3 for healthy controls (black bars) and 5 for diabetic mice (gray bars). At least 3 visual fields were evaluated for each mouse. The mean ± SD is reported; **P < 0.005. Magnification, ×40. (B) Mean hind-paw lick latency in the hot-plate assay (50–C) in WT and RAGE–/– mice that were healthy (black bars) or had had diabetes for 6 months (gray bars). The number of mice studied was 6 for WT controls, 10 for WT mice with diabetes, 10 for RAGE–/– control mice, and 9 for RAGE–/– mice with diabetes. The mean ± SD is reported; *P < 0.05; **P < 0.005. (C) Extent of diabetes-induced loss of pain perception, evidenced by the increase (Ø) in paw lick latency in WT (light gray bar) and RAGE–/– (dark gray bar) mice. The mean ± SD is reported; *P < 0.05.