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. 2004 Dec 15;114(12):1752–1761. doi: 10.1172/JCI21625

Figure 4.

Figure 4

Decreased mRNA expressions and activities of antioxidant enzymes in WAT of obese KKAy mice. (A) The mRNA expressions of Cu,Zn-SOD, Gpx, and catalase in WAT, liver, and skeletal muscle of C57BL/6 (white bars) and KKAy (black and gray bars) mice at 7 and 13 weeks of age. Values are normalized to the level of cyclophilin mRNA, and expressed as mean ± SEM (n = 6–8). (B) Immunoblot analysis of the amount of Cu,Zn-SOD protein in WAT, liver, and skeletal muscle of C57BL/6 and KKAy mice at 7 and 13 weeks of age. (C) Total SOD activities (left) and GPx activities (right) in WAT, liver, and skeletal muscle of C57BL/6 (white bars) and KKAy (black and gray bars) mice at 7 and 13 weeks of age. Values are expressed as mean ± SEM (n = 6–8). (D) Model illustrating increased production of oxidative stress in accumulated fat. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with C57BL/6 mice.

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