Skip to main content
. 2004 Dec 15;114(12):1800–1811. doi: 10.1172/JCI22046

Figure 5.

Figure 5

CD8+ T cell responses induced by injection of MHC class I–binding peptides can be enhanced by coadministration of α-GalCer. (A) OVA257–264 peptide (100 μg/mouse) was injected i.v. together with either α-GalCer or vehicle, and induction of specific CD8+ T cell responses was assessed in blood 7 days later. (B) One week after peptide priming, OVA257–264–specific CD8+ T cell responses were restimulated in vivo by i.v. injection of vacc-OVA (5 × 105 PFU/mouse). Responses induced 7 days after restimulation are presented together with those observed in control animals that received vaccinia alone and those of a naive group. (C) Specific CD8+ T cell responses were monitored in A2Kb-transgenic mice after i.p. injection of NY-ESO-1157–165 (V) peptide together with either α-Gal-Cer or vehicle. (D) The induced responses shown in C were restimulated by i.v. injection of vacc–NY-ESO-1 (1 × 106 PFU/mouse) 7 days later.

HHS Vulnerability Disclosure