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. 2010 Aug 18;3(4):158–169. doi: 10.1111/j.1752-8062.2010.00212.x

Figure 5.

Figure 5

FD blunt MC‐driven anaphylaxis in vivo. Mice (5 per group) were sensitized with 50 μg DNP‐IgE in 100 μl PBS. Two hours later the mice were injected i.p. with PBS alone or 100 ng of FD that inhibit degranulation and cytokine production (A) or cytokine production only (B) in 100 μL PBS. The following day rectal temperatures were recorded before mice were challenged i.p. with 100 μg of DNP‐BSA in 100 μL PBS. Temperatures were recorded every 10 minutes (up to 50 minutes) following challenge with DNP‐BSA. (C) Increases in antigen‐induced serum histamine release is blunted by FD. Blood was collected from control (black bars), degranulation inhibiting FD (light gray bars) or cytokine inhibiting FD (dark gray bars) at 50 minutes and histamine content determined by ELISA.