Table 1.
Degranulation (±SD) and GMCSF‐cytokine production (±SD) in TGA treated and untreated mice.
| Mean percent degranulation (±SD) in TGA treated and untreated MC | |||||
|---|---|---|---|---|---|
| Mast cells | |||||
| no XL | XL | TGA+XL*† | %inh | IC50 (μg/mL) | |
| Exp 1 | 3.4 | 76.7 | 39.1 | 48.9 | |
| Exp 2 | 3.2 | 81.1 | 50.1 | 38.2 | |
| Exp 3 | 5.5 | 74.5 | 53.4 | 28.3 | |
| Exp 4 | 4 | 77.9 | 40.1 | 48.5 | |
| Exp 5 | 8.1 | 78.5 | 52.7 | 32.8 | |
| Average | 4.8 (±2.0) | 77.7 (±2.4) | 47.1 (±6.9) | 39.3 (±9.2) | 10.9 (±3.5) |
| Mean percent GMCSF‐cytokine production (±SD) in TGA treated and untreated MC | |||||
|---|---|---|---|---|---|
| Mast cells | |||||
| no XL | XL | TGA+XL*† | %inh | IC50 (μg/mL) | |
| Exp 1 | 50.4 | 211.4 | 69.5 | 67.8 | |
| Exp 2 | 135.4 | 893.8 | 121.9 | 84.9 | |
| Exp 3 | 91.6 | 309.5 | 104.5 | 66.2 | |
| Exp 4 | 65.4 | 271.4 | 74.1 | 72.7 | |
| Exp 5 | 105.4 | 741 | 43.4 | 95.2 | |
| Average | 89.6 (±33.4) | 485.4 (±309.8) | 82.7 (±30.8) | 77.4 (±12.4) | 3.3 (±0.6) |
* TGA Treatment @ 10 μg/mL.
† p value = 0.0001.
* TGA Treatment @ 10 μg/mL.
†p value = 0.02.