Table 2.
Degranulation (±SD) and GMCSF‐cytokine production (±SD) in Inos treated and untreated mast cells.
| Mean percent degranulation (±SD) in Inos treated and untreated MC | |||||
|---|---|---|---|---|---|
| Mast cells | |||||
| no XL | XL | Inos+XL*† | %inh | IC50 (μg/mL) | |
| Exp 1 | 3.4 | 76.7 | 78.1 | 1.9 | |
| Exp 2 | 3.2 | 81.1 | 80.3 | 1 | |
| Exp 3 | 5.5 | 74.5 | 70.2 | 5.8 | |
| Exp 4 | 4 | 77.9 | 75.5 | 3.1 | |
| Exp 5 | 8.1 | 78.5 | 91.6 | 16.8 | |
| Average | 4.8 (±2.0) | 77.7 (±2.4) | 79.1 (±7.9) | 3.3 (±2.4) | |
| Mean percent GMCSF‐cytokine production (±SD) in Inos treated and untreated MC | |||||
|---|---|---|---|---|---|
| Mast cells | |||||
| no XL | XL | Inos+XL*† | %inh | IC50 (μg/mL) | |
| Exp 1 | 50.4 | 211.4 | 11.9 | 94.4 | |
| Exp 2 | 135.4 | 893.8 | 20.4 | 97.7 | |
| Exp 3 | 91.6 | 309.5 | 23.5 | 92.4 | |
| Exp 4 | 65.4 | 271.4 | 63.1 | 76.8 | |
| Exp 5 | 105.4 | 741 | 43.4 | 95.2 | |
| Average | 89.6 (±33.4) | 485.4 (±309.8) | 32.5 (±20.6) | 91.3 (±8.3) | 1.9 (±1.1) |
*Inos Treatment @ 10 μg/mL.
†p value = 0.358.
* Inos Treatment @ 10 μg/mL.
†p value = 0.006.