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. 2009 May 8;2(3):183–192. doi: 10.1111/j.1752-8062.2009.00099.x

Table 1.

List of genes that were preselected for analysis based on biological information and encompassing erbB receptors or ligands, downstream or associated genes (including genes in the public domain that were associated with disease types other than SCCHN), or genes identified from previous preclinical and clinical studies as well as from the literature.

Gene Gene name
ABCA2 ATP‐binding cassette, subfamily A, member 2
ABCB1 ATP‐binding cassette, subfamily B, member 1
ABCC2 ATP‐binding cassette, subfamily C, member 2
ABCC3 ATP‐binding cassette, subfamily C, member 3
ABCC4 ATP‐binding cassette, subfamily C, member 4
ABCC5 ATP‐binding cassette, subfamily C, member 5
ABCG2 ATP‐binding cassette, subfamily G, member 2
AC0×2 Acyl‐coenzyme A oxidase 2
ADAM10 a disintegrin and metalloproteinase domain 10 (= Kuzbanian)
ADAM9 a disintegrin and metalloproteinase domain 9
AKT1 v‐akt murine thymoma viral oncogene homolog 1
AKT2 v‐akt murine thymoma viral oncogene homolog 2
AKT3 v‐akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
AREG Amphiregulin
AVEN Apoptosis, caspase activation inhibitor
BAD BCL2 antagonist of cell death
BAG1 BCL2‐associated athanogene
BCL2 BCL2/adenovirus E1B, 19 kD, protein‐interacting protein 3a
BCL2L1 Apoptosis regulator Bcl‐x (BCL2‐like protein)
BCLW Apoptosis regulator Bcl‐w (BCL2‐like protein)
BRAF v‐raf murine sarcoma viral oncogene homolog B1
BTC Beta‐cellulin
CBL Cas‐Br‐M (murine) ecotropic retroviral transforming sequence
CDH1 E‐cadherin
CDK4 Cyclin‐dependent kinase 4
CDK6 Cyclin‐dependent kinase 6
CHST7 Carbohydrate (N‐acetylglucosamine 6‐O) sulfotransferase 7
C0L4A3B Collagen, type IV, alpha 3‐binding protein
C0R01C Coronin, actin‐binding protein, 1C
CSNK2A1 Casein kinase 2, alpha 1 polypeptide
DAPK1 Death‐associated protein kinase 1
DAPK2 Death‐associated protein kinase 2
DUSP3 Dual‐specificity phosphatase 3
EGF Epidermal growth factor
EGFR Epidermal growth factor receptor (erythroblastic leukemia viral [v‐erb‐b] oncogene homolog, avian)
ELK1 ELK1, member of ETS oncogene family
EMP1 Carbohydrate (N‐acetylglucosamine 6‐O) sulfotransferase 7
ERBB2 v‐erb‐b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma‐derived oncogene homolog (avian)
ERBB3 v‐erb‐b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
ERCC1 Excision‐repair cross‐complementing rodent repair deficiency
EREG Epiregulin
ESR1 Estrogen receptor 1
FLJ22662 Hypothetical protein FLJ22662
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS‐like antigen 2
FOXF1 Forkhead
FRAP1 FK506‐binding protein 12‐rapamycin‐associated protein 1
Fos v‐fos FBJ murine osteosarcoma viral oncogene homolog
GAK Cyclin G‐associated kinase
GCLC Glutamate‐cysteine ligase, catalytic subunit
GSH Glutathione synthetase
GSK3A Glycogen synthase kinase 3 alpha
GSK3B Glycogen synthase kinase 3 beta
GSPT2 Gl to S phase transition 2
GSTP1 Glutathione S‐transferase Pi
HB‐EGF Heparin‐binding EGF
HRAS v‐Ha‐ras Harvey rat sarcoma viral oncogene homolog
IGF1 Insulin‐like growth factor 1
IGF1R Insulin‐like growth factor 1 receptor
IGF2 Insulin‐like growth factor 2
JUN v‐jun sarcoma virus 17 oncogene homolog (avian)
JUNB Jun B proto‐oncogene
JUND Jun D proto‐oncogene
KRAS2 v‐Ki‐ras2 Kirsten rat sarcoma viral oncogene homolog
MAP2K1 Mitogen‐activated protein kinase kinase 1 (MEK)
MAP2K2 Mitogen‐activated protein kinase kinase 2
MAP3K1 Mitogen‐activated protein kinase kinase kinase 1 (MEKK)
MAPK1 Mitogen‐activated protein kinase 1
MAPK3 Mitogen‐activated protein kinase 3
MCL1 Myeloid leukemia 1
MGMT O‐6‐methylguanine DNA methyltransferase
MOSPD1 Motile sperm domain‐containing 1
MVP Major vault protein
NES Nestin
NOTCH3 Notch homolog 3
NPAS2 Neuronal PAS domain protein 2
NRAS Neuroblastoma RAS viral (v‐ras) oncogene homolog
NRG1 Neuregulin 1
OSMR Oncostatin M receptor
PAK1 p21/Cdc42/Racl‐activated kinase 1
PAK2 p21 (CDKNlA)‐activated kinase 2
PAK4 p21 (CDKNlA)‐activated kinase 4
PAK6 p21 (CDKNlA)‐activated kinase 6
PDPK1 3‐phosphoinositide‐dependent protein kinase‐1
PGM1 Phosphoglucomutase 1
PHLDA2 Pleckstrin homology‐like domain, family A, member 2
PIK3CA Phosphoinositide‐3‐kinase, catalytic, alpha polypeptide
PIK3CB Phosphoinositide‐3‐kinase, catalytic, beta polypeptide
PIK3R1 Phosphoinositide‐3‐kinase, regulatory subunit, polypeptide 1 (p85, alpha)
PIK3R2 Phosphoinositide‐3‐kinase, regulatory subunit, polypeptide 2 (p85, beta)
PIK3R3 Phosphoinositide‐3‐kinase, regulatory subunit, polypeptide 3 (p55, gamma)
PLCG1 Phospholipase C, gamma 1 (formerly subtype 148)
RAF1 v‐raf‐1 murine leukemia viral oncogene homolog 1
RASGRP1 RAS guanyl‐releasing protein 1 (calcium‐ and DAG‐regulated)
RBM7 RNA‐binding motif protein 7
RPS6KA1 Ribosomal protein S6 kinase, 90 kD, polypeptide 1
RPS6KA2 Ribosomal protein S6 kinase, 90 kD, polypeptide 2
RPS6KA3 Ribosomal protein S6 kinase, 90 kD, polypeptide 3
RPS6KA4 Ribosomal protein S6 kinase, 90 kD, polypeptide 4
RPS6KB1 Ribosomal protein S6 kinase, 70 kD, polypeptide 1
RPS6KB2 Ribosomal protein S6 kinase, 70 kD, polypeptide 2
SHC1 SHC (src homology 2 domain‐containing) transforming protein 1
SIAT9 ST3 beta‐galactoside alpha‐2,3‐sialyltransferase 5
SLC20A1 Solute carrier family 20 (phosphate transporter), member 1
SOS Son of sevenless protein homolog 1
SPRY2 Sprouty homolog 2
SRC v‐src sarcoma (Schmidt‐Ruppin A‐2) viral oncogene homolog (avian)
STAT1 Signal transducer and activator of transcription 1, 91 kD
STAT3 Signal transducer and activator of transcription 3 (acute‐phase response factor)
STAT5A Signal transducer and activator of transcription 5A
STAT5B Signal transducer and activator of transcription 5B
STK12 Serine/threonine kinase 12 = Aurora B
STK6 Serine/threonine kinase 6 = Aurora A
TACE Tumor necrosis factor, alpha, converting enzyme
TGF‐α Transforming growth factor alpha
TNNC1 Troponin C, slow
VEGF Vascular endothelial growth factor A
p27KIP Cyclin‐dependent kinase inhibitor 1B