Table 2.

Gene transcripts associated with sensitivity to gefitinib, identified from the hypothesis‐driven gene set. Genes were preselected for analysis based on biological information and encompassed erbB receptors or ligands, downstream or associated genes (including genes that were associated with disease types other than SCCHN), or genes identified from previous preclinical and clinical studies as well as from the literature.

Gene	Gene name	Fold change in sensitive vs. resistant cell lines	p value
CDH1	Cadherin 1, type‐1 preproprotein	156.12	<0.001
TGF‐α	Transforming growth factor, alpha	13.15	<0.001
AREG	Amphiregulin	9.40	0.001
FLJ22662	Hypothetical protein FLJ22662	8.34	0.006
EGFR	Epidermal growth factor receptor (erythroblastic leukemia viral [v‐erb‐b] oncogene homolog, avian)	7.48	0.009
PAK6	p21‐activated kinase 6	5.81	<0.001
GSTP1	Glutathione s‐transferase Pi	4.72	0.004
ABCC5	ATP‐binding cassette, subfamily c, member 5 isoform 1	3.32	<0.001