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. 2009 Feb 18;2(1):41–49. doi: 10.1111/j.1752-8062.2008.00076.x

Figure 3.

Figure 3

Figure 3

Effect of IL‐6 treatment and GQ‐ODN pretreatment on lung Stat3 activation within the lungs. Rats were subjected to sham (S) protocol, T/HS treated with placebo at the beginning of resuscitation (SBR50), T/HS treated with IL‐6 at the beginning of resuscitation (SBR50/IL‐6), T/HS preceded by treatment with GQ oligodeoxynucleotide (GQ‐ODN) 24 hours prior to resuscitation with IL‐6 (SBR50/IL‐6/G), or T/HS preceded by treatment with nonspecific ODN (NS‐ODN) 24 hours prior to resuscitation with IL‐6 (SBR50/IL‐6/N). The lungs were harvested 60 minutes after the start of resuscitation. (A) Protein extracts of whole lung were immunoblotted for phosphorylated (p)Stat3 and total Stat3. Bands representing Stat3α, Stat3β, and Stat3δ are indicated on the right. 51 , 52 (B) The pStat3 and total Stat3 bands were quantitated by densitometry and data are presented as mean ± SEM of pStat3 signal corrected for total Stat3 signal for each group. Bars marked with an asterisk (*) differ significantly within the pair (p < 0.0001).