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Relationship of the COMT Val158 genotype to endogenous opioid release following alcohol consumption. Endorphin release is significantly greater in the right NAc (A: t = 3.25, p = 0.009) and significantly lower in the left mOFC (B: t = 2.34, p = 0.041) and right mOFC (C: t = 2.60, p = 0.027) of individuals with the Val/Val genotype. Blue circles indicate control subjects, red circles indicate heavy social drinkers.
