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. 2016 Jun 20;9(5):246–251. doi: 10.1111/cts.12403

Table 4.

Pharmacokinetic bioequivalence tests compared with synthetic control over 240 min postdose (n = 12)

Source Cmax ratio tmax difference t1/2 difference AUC0–4h ratio AUC0–∞ ratio
Guayusa leaf

  • 1.00 ± 0.16

  • (0.91 − 1.08)

  • –25.00 ± 65.02

  • p = 0.178+

  • –20.50 ± 167.82[Link]

  • p = 0.966+

  • 1.00 ± 0.02

  • (0.99 − 1.02)

  • 1.01 ± 0.07[Link]

  • (0.97 − 1.05)
Green coffee

  • 0.97 ± 0.14

  • (0.89 − 1.04)

  • –12.50 ± 61.96

  • p = 0.590+

  • 0.99 ± 0.04

  • (0.97 − 1.01)

  • 1.01 ± 0.10*

  • (0.95 − 1.06)

Ratios are presented as mean ± standard deviation with 90% confidence intervals. Cmax and AUCs were log transformed before taking the ratios.

+ P–values are from a Wilcoxon paired test compared with synthetic control.

* n = 11.