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. 2015 May 22;8(4):298–304. doi: 10.1111/cts.12275

Figure 1.

Figure 1

Sodium channel blockers mexiletine and prilocaine decrease DMPK mRNA in vitro. C2C12 cells were treated with range of doses of sodium channel blockers (0 [n = 6], 50 nM [n = 3], 1 μM [n = 6], and 25 μM [n = 6])} for 4 hours and then harvested for RT‐PCR. (A) Quantification of DMPK mRNA relative to β‐2‐microglobulin (the ratio of control group is set as 1) upon treatment with mexiletine. (B) Quantification of DMPK mRNA relative to β‐2‐microglobulin (the ratio of control group is set as 1) upon treatment with prilocaine. (A) Quantification of DMPK mRNA relative to β‐2‐microglobulin (the ratio of control group is set as 1) upon treatment with procainamide. Mean ± SEM (bars) of three independent experiments are shown. *p < 0.05; **p < 0.01; ***p < 0.001, t‐test.